Bring on the noise bring on the notification fatigue

How do I gain control of my online social life:

I have the Seesmic desktop client running with 7 twitter accounts ranging from 10 to 1000′s of followers plus several active searches. The thing is out of control and requiring my full attention.  The concept that twitter is a one way communication is just not true it’s like Facebook, IM or email, certain posts require a response and most are looking for a very timely reply.

I have given up on IM for the time being, I check Facebook and linkedin at least once a day and my email client is always active and taking up way to much space.

What should I do, if I want to be responsive to those who need or want my attention?